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This review explores the application of natural metabolites used in TCM in the prevention and treatment of major cardiovascular diseases, highlighting their pharmacological mechanisms and therapeutic potential

Key pathways identified in published research include: Growth hormone receptor upregulation: Several Sikiric-group papers report that BPC-157 upregulates GH receptor expression in tendon fibroblasts, which may explain accelerated tendon-to-bone healing observed in rat models

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A larger amount of vitamin B12 is mostly found in beef, liver, and chicken

Melatonin is an OTC hormone supplement that mainly shifts sleep timing through the circadian system